KMID : 0438520080150020196
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Journal of the Korean Society of Neonatology 2008 Volume.15 No. 2 p.196 ~ p.199
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Neonatal Intestinal Pseudo-obstruction Associated with Deficiency of the Interstitial Cells of Cajal in a Premature Infant
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Lee Soo-Jung
Lee Woo-Ryoung
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Abstract
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The interstitial cells of Cajal are the pacemakers in the gastrointestinal tract that modulate gastrointestinal motility. A case of a neonate with intestinal pseudo-obstruction caused by a decreased number of the interstitial cells of Cajal is presented. A premature male infant born at 32 weeks of gestation showed progressive abdominal distention beginning 3 days after initiation of enteral feeding at 15 days of life. No etiologic factors were identified on radiologic studies, a gastrographin enema, and an intestinal biopsy other than a markedly decreased number of the intestinal cells of Cajal. An ileostomy, followed by repair of the ileostomy was done, which resulted in but a limited improvement of the abdominal gas pattern. Respiratory distress, pancytopenia, and abdominal distention persisted, and the infant expired on 142 days of life.
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KEYWORD
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Intestinal pseudo-obstruction, Interstitial cells of Cajal, Premature infant
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